Phrases interview COVID and the vaccine

I don’t have much experience of explaining science to the lay public

Lay public-in this case individuals who don’t have an academic background in the medical sciences.

…. this last year has been a massive learning curve for me!

Learning curve-in this situation it relates to the need to learn a lot in a short period of time.

So, what you then do is that you unblind the study and you look to see who the people who’ve been infected are and the vast majority of them received the placebo, so actually of the people who received the vaccine, very few caught COVID.

Unblind the study-at the start the study was a blind study, when a study is blind the participants do not know whether they are receiving the actual treatment, in this case the vaccine or a placebo.

 It has moved phenomenally quickly; usually, vaccine development takes eight years plus to come to the market. 

Come to market-available for sale/distribution.

Every medication has side effects, so if you think of something like paracetamol, a type of plaster, or a COVID vaccine, a small minority will react. 

Side effects-in this case the vaccines’ purpose is to protect people against COVID but something that is not intended is that people might feel ill for a short while after being given the vaccine, for example they may have a slight fever, feel fatigued etc these are side effects of the vaccine.

mRNA technology is being used in cancer treatments, and they’ve published a study of mRNA technology used in an animal model of multiple sclerosis. So, it’s a really exciting technology. 

Animal model-experimental living systems where treatments can be tested.

There are also some indications that natural immunity potentially does wane, its quite hard to interpret.

Wane-in this case strength of the response decreases.

There’s a lot of research into things like this; so, this is an example of a conspiracy theory there’s been quite a lot of research into the psychology of conspiracy theories.

Conspiracy theory-a theory that dismisses the standard interpretation of events and choses an explanation that points towards motives of personal/political gain.

Some people will come round; some people will not.

Come round-to change one’s opinion on something

People who are very anti-vaccine are very influential on social media; they sit at the center of social networks.

Social media-facebook, twitter, Instagram. Social networks-groups of people connecting via social media.

We need regular vox pops of people who’ve been vaccinated, starting with granny and working downwards.

Vox pops-voice of the people.

and inserting something as fact when it’s based on something that’s happened but delivered out of context.

Out of context-in this case only talking about certain facts so that it looks like their concerns are validated.

Follow-up to the COVID interview (level C1)

I initially had the interview with the scientist earmarked for another blog. The original interview was conducted in March, you can read it here:

https://racheldoesinterviews.com/2020/09/04/coronavirus-some-of-the-science-behind-it/

I moved the interview to this blog because it is more accessible and I wanted to update the science to show how the scientific process works. I hope to interview the virologist again to give readers an update on the COVID situation wrt science.

This blog post will be dedicated to my personal update regarding the situation. 

As stated in the previous interview, certain drugs were trialled for COVID-19.

The first drug mentioned in my previous post was hydroxychloroquine. The initial stages of an investigation into a drug look at what is known as in vitro testing, which is a Latin expression meaning “in the glass”; this stage of the testing tests the medication being trialed by using cells in a test tube. Sometimes, a procedure that works in vitro does not work in vivo (in the body); this is because the body is complex, and what works at the cellular level in a test tube does not necessarily work when it is tried in living humans.

Hydroxychloroquine was tested in multiple trials and showed no benefit when it came to post-exposure prophylaxis* or in treating COVID-19.

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30390-8/fulltext

Trials of Remdesivir were conducted as a medication to treat COVID 19 because it is a general anti-viral medication. Remdesivir blocks the activity of an enzyme that is needed for viral replication. In vitro, Remdesivir, and Interferon-beta had an effect against SARS-CoV-2, the virus that causes COVID-19.

Results for Remdesivir have been mixed. To find out more, follow this link:

https://acpinternist.org/weekly/archives/2020/10/20/2.htm

Factors that can lead to mixed results in clinical trials include:

  • how long the individual has been ill
  • their age
  • issues with statistical power (i.e., whether there are enough individuals in the trial to make the results meaningful), among other things.

Interferon-beta was trialed for COVID-19 since it worked against hepatitis C which is in some ways similar. Interferon-beta worked against hepatitis C by stimulating the activity of immune cells and resulting in virus-infected cells being more susceptible to the immune response.

The findings for Interferon-beta-1a are promising, and further trials would help determine how effective it is in terms of COVID 19 treatment. See the following link for more details:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30523-3/fulltext

If I am able to arrange a second interview with the virologist, I hope to look at the following:

  • Human trials and how they are used to test certain medications.
  • What we now know about the immune response to COVID-19
  • What the science says about herd immunity (I personally feel that letting a virus run unchecked through the population is a bad idea and that genuine herd immunity achieved through vaccination) and what the stance of the scientific community is in general regarding this question
  • Why the vaccine is fine even though it’s been developed in a faster time frame than is normally the case

Stay tuned for a possible update..

*post-exposure prophylaxis is a preventative medical treatment that needs to be taken in a specific time frame in order to prevent an infection from occurring